2016 Nov;95(46):e5377. doi: 10.1097/MD.0000000000005377.Dudesek A, Rimmele F, Tesar S, Kolbaske S, Rommer PS, Benecke R, Zettl UK.Clin Exp Immunol. Name must be less than 100 characters 2019 Nov 4;19(1):266. doi: 10.1186/s12883-019-1507-z.Medicine (Baltimore). Whether CLIPPERS represents an independent, actual new disorder or a syndrome that includes aetiologically heterogeneous diseases and/or their prestages remains a debated and not finally clarified issue.
CLIPPERS syndrome may become manifest with a progressive tumor-like pontine lesion. Enter and update disclosures at The most widely read and highly cited peer-reviewed neurology journalClinical, Radiographic and Pathological Features of CLIPPERS (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) (P6.109) Diagnostic uncertainty is common in the absence of defining biomarkers. There is currently a discussion whether CLIPPERS is a disease or a syndrome. We were concerned about the double vision and his eye dr. said that his eyes were fine. Marked clinical and radiological corticosteroid responsiveness was observed in CLIPPERS (23/23), and clinical worsening occurred in all 12 CLIPPERS cases when corticosteroids were discontinued. Unable to load your delegates due to an error
It may be associated with lymphoma and macrophage activation, while the related report of histiocytes (macrophage) activation involved in pathogenesis of CLIPPERS is rare. NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. No comments have been published for this article.
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Pathogenesis of CLIPPERS remains poorly understood, and the nosological position of CLIPPERS has still to be established.
Background: CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a chronic central nervous system (CNS) inflammatory disorder.
2016 Aug;95(34):e4640. (Message moved into the forum by Bill Crum) Hi Tom, My husband who recently turned 61 was diagnosed with CLIPPERS syndrome in September of last year. 2010 Sep;133(9):2626-34. doi: 10.1093/brain/awq164. Clinical symptoms of gait ataxia, diplopia, cognitive impairment, and facial paraesthesia did not discriminate CLIPPERS from non-CLIPPERS.
Around the holidays of 2011 he started to get double vision and then became very fatigued.
Epub 2010 Jul 17.Hou X, Wang X, Xie B, Lin W, Liu J, Ma D, Zhang HL.Medicine (Baltimore). doi: 10.1097/MD.0000000000004640. 2014 Mar;175(3):385-96. doi: 10.1111/cei.12204.Pittock SJ, Debruyne J, Krecke KN, Giannini C, van den Ameele J, De Herdt V, McKeon A, Fealey RD, Weinshenker BG, Aksamit AJ, Krueger BR, Shuster EA, Keegan BM.Brain. Declaration of Competing Interest The authors report no competing interests.
Elsevier Science Reports of development of primary lymphoma of central nervous system, and autoantibodies positivity in some patients initially diagnosed as CLIPPERS, suggests an overlap with … Klippel Feil syndrome (KFS) is a condition affecting the development of the bones in the spine. NOTE: The first author must also be the corresponding author of the comment.Your role and/or occupation, e.g.
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