The computational chemistry expertise is provided by Professor Thomas Frimurer. Dr. Frimurer, who has 15+ years of experience with structure-based chemical design technologies in academia and Pharma/Biotech, is head of a group focusing at Chemical and Molecular Receptology (computational chemistry). (7)Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DL-2200 Copenhagen, Denmark; thomas.frimurer@sund.ku.dk. While the molecular basis of agonist binding has been addressed in several studies, the concept of biased agonism of EBI2 has...The G-protein coupled receptor 39 (GPR39) is a G protein-coupled receptor activated by Zn²⁺. The method focused on a putative binding site in GPR39 for synthetic ligands and knowledge of ligand binding to other receptors wi...The small molecule metal-ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3-binding to CCR5, weak modulators of CCL4-binding, and as competitors for CCL5-binding. We used a homology model-based approach to identify small-molecule pharmacological tool compounds for the receptor. Here we describe their binding site using computational modeling, binding and functio...The human cytomegalovirus-encoded G protein-coupled receptor US28 is a constitutively active receptor, which can recognize various chemokines. Prof. Groth was elected as a member of the Royal Danish Academy of Sciences and Letters in 2016 and EMBO in 2017 for her seminal work on epigenetics and genome stability. The G protein-coupled receptor Epstein Barr virus-induced gene 2 (EBI2, also known as GPR183) is activated by oxysterols and plays a pivotal role for proper B cell migration during immune responses. Frimurer, who has 15+ years of experience with structure-based chemical design technologies in academia and Pharma/Biotech, is head of a group focusing at Chemical and Molecular Receptology (computational chemistry). See Photos.

Currently he is a co-founder of Ankrin Therapeutics and holds the position as Associate Professor at University of Copenhagen where he is head of a group focusing at Chemical and Molecular Receptology (computational chemistry).Dr. U-2-OS cells expressing Flag-HA-BARD1 WT or ARD 3A were pulsed with EdU, irradiated with 1 Gy and 45 minutes later pre-extracted and analysed by immunofluorescence. Thomas Frimurer – Molecular modeling and structure-based drug design. Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to … The recruitment of b-arrestin2 was measured using the PathHunter b-arrestin assay (DiscoverX) as described previously ... An arbitrary cut-off at "Sum RNA" <100 and "Sum Protein" <50 revealed PTH2R, GPR39 (orphan receptor with known synthetic agonists), ADGRG2 (orphan receptor), OXTR and LPAR3 as the most promising candidates. Prof. Anja Groth holds a PhD in Molecular Biology from University of Copenhagen (2004) based on her research on genome stability at the Danish Cancer Society with Drs. Most downloaded Thomas Frimurer. From the orphan receptors ADGRG2 and GPR39, the former was discarded from the final selection due to lack of known agonists, while the latter was retained due to the recent discovery of synthetic agonists ... Ion channels are involved in a variety of key cellular functions and are considered very attractive targets for therapeutic intervention [1][2][3][4]. Research outputs Thomas M. Frimurer Thue W. Schwartz It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. myrtenol as positive allosteric modulator a...Background and purpose: From 2002-2012 employed at NeuroSearch and as Head of Medicinal Chemistry and Project Director worked across strategic collaborations between biotech and big pharma.
Associate Professor. Structural Biology / Biophysics: Guillermo Montoya, Alex Toftgaard Nielsen, Thue Schwartz, Josh Brickman, Elke Ober, Jakub Sedzinski, Nicholas Taylor, Ditte Hededam Welner, Thomas Frimurer See more

Frimurer TM, et al. In 2008, Prof. Groth started a research group at Biotech Research and Innovation Centre (BRIC), University of Copenhagen, and in 2016 she was promoted to professor. In addition to my responsibilities as an Associate Professor, I am a co-founder of Ankrin Theapeutics, a company developing innovation in the field of cancer therapy. In addition to my responsibilities as an Associate Professor, I am a co-founder of Ankrin Theapeutics, a company developing innovation in the field of cancer therapy. Positive allosteric modulators of GABAA receptors have been reported either isolated from plants or synthesized analogs of known GABAA receptor targeting drugs. (2017) Model-based discovery of synthetic agonists for the Zn 2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions. Structural Biology / Biophysics: Guillermo Montoya, Alex Toftgaard Nielsen, Thue Schwartz, Josh Brickman, Elke Ober, Jakub Sedzinski, Nicholas Taylor, Ditte Hededam Welner, Thomas Frimurer

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