Please go ahead.Sachin Jain here. So it's clear that we are very encouraged by the clinical profile we have seen not only for semaglutide in obesity, but clearly also AM833 alone and in combination with semaglutide. Further, Novo Nordisk signed an agreement for the acquisition of Corvidia Therapeutics, including the Phase IIb project, ziltivekimab. Such forward-looking statements are subject to risks and uncertainty that could cause actual results to differ materially from expectations.For further information on the risk factors, including the uncertainties around COVID-19, please see the company announcement for the first half of 2020 and the slides prepared for this presentation. In 1923, Nordisk Insulinlaboratorium began marketing the first Scandinavian insulin.Novo Nordisk’s origins go as far back as insulin therapy itself; the company began over 90 years agoTwo early hires by Nordisk Insulinlaboratorium were brothers Harald and Thorvald Pedersen, a machinist and pharmacist respectively, to oversee the insulin production process. So with that, thank you, Martin.Thank you, sir. Please note that this conference call is being webcasted live, and a recording will be made available on Novo Nordisk's website.

Research and development costs increased by 13% in Danish kroner and by 13% at constant exchange rates. Please go ahead with your meeting.Thank you. This 20 week multiple ascending dose trial investigated the safety tolerability pharmacokinetics and weight loss potential of AM833 administered in combination with semaglutide 2.4 milligrams in 80 people with obesity or overweight.After only 20 weeks of treatment and with only the last four weeks at the therapeutic doses of 2.4 milligram semaglutide plus AM833, patients in the trial lost an average of 17.1% body weight from a mean baseline of 95.1 kilograms. And so again, sort of more looking forward, given that we now have COVID to contend with, do you anticipate more slowing down of GDP growth impacting your business or potential for governments rebuilding balance sheets and they're facing debt mountain to have to reduce prices potentially a little bit more than you'd expected back then? Following completion of the four STEP trials, Novo Nordisk will now prepare to file the regulatory dossier, an NDA submission, which is expected to take place around the turn of the year. to a complaint or a side effect will be processed in accordance with Read more {{'2020-08-06T05:30:38Z' | dateFormatFilter}} Novo Nordisk's operating profit increased by 9% in Danish kroner and by 8% at constant exchange rates (CER) in the first six months of 2020. So very optimistic, Mads, on obesity, so that's great. Just wondering whether some of the unemployment changes, whether you've changed the rebate structure in those to anticipate going forward?

So we have seen some signs of recovery, but not completely there. The growth includes COVID-19-related stocking, which was largely offset by fewer patients initiating treatment as well as other timing events. Then we have the channel mix and the payer mix impacting. So I'm just wondering if you could just tell us your thoughts on what you think might happen with regard to potential U.S. healthcare reform and with a particular reference to international reference price?

And 1% should be seen in the light of the coverage gap you talked to, which has an impact to the tune of two percentage point on growth as well as affordability initiatives.Then, as I said before, then, of course, U.S. employment will have a negative impact on our channel mix because some people will move from the employer-sponsored health plans.
So you will see that coming up very soon. The recent executive orders, two of them deal will increased pass-through rebates to patients. The reimbursement negotiations are generally going very well, and we are achieving also reimbursement at price levels in the GLP-1 ballpark, so around the same level as you see for Ozempic and other GLP-1s in Europe. Company Participants. With me, I have our Chief Financial Officer, Karsten Munk Knudsen; and our Chief Science Officer, Mads Krogsgaard Thomsen. The past months have been highly unusual given the COVID-19 pandemic. Salaries posted anonymously by Novo Nordisk employees. Could you give us some idea on timing and your thoughts there?Thank you, Richard. And it's clear that, that statement was said with confidence that we would also get strong clinical data. Put simply, we’ve raised the innovation bar that our future portfolio must clear if the products are to be commercially viable.”“Fortunately, I was able to spend the last four months of 2016 preparing to take up the position of CEO of Novo Nordisk. As well as the increase of diabetes in the global population, this success can be attributed to a string of management decisions that championed both core products and social responsibility over aggressive tactics.Novo Nordisk is primarily owned by the Novo Nordisk Foundation. Thank you very much for taking my questions. Please turn to slide 14. the safety of our products.If you have experienced a side effect or complaint to a Novo Nordisk The increase was driven by timing of rebate payments in the U.S., the increase in net profit as well as lower capital expenditure.


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